SCHEMBL8108312

SCHEMBL8108312

O=c1oc2c(O)c(O)ccc2cc1-c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 10/20 0.70
ADORA1 P30542 9/20 0.70
ADORA3 P0DMS8 7/20 0.70
TMIGD3 P0DMS9 3/20 0.56
KDM4E B2RXH2 1/20 0.56
GAA P10253 1/20 0.56
RECQL P46063 1/20 0.56
MAOA P21397 2/20 0.54
MAOB P27338 2/20 0.54
STS P08842 1/20 0.53
CA12 O43570 2/20 0.51
CA9 Q16790 2/20 0.51
XDH P47989 1/20 0.48
MAPT P10636 2/20 0.47
ALDH1A1 P00352 1/20 0.47
POLB P06746 1/20 0.47
CTDSP1 Q9GZU7 1/20 0.47
MEN1 O00255 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6480420 0.84 ADORA3 (0.54) ADORA2AADORA1ADORA3KDM4EGAA
SCHEMBL22129747 0.83 ADORA2A (1.00) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL8116446 0.80 ADORA1 (0.78) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL8123512 0.80 ADORA1 (0.78) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL8122028 0.80 ADORA1 (0.78) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL8124488 0.80 ADORA3 (0.78) ADORA2AADORA1ADORA3TMIGD3MAOA
SCHEMBL8121046 0.80 ADORA2A (1.00) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL22132747 0.80 ADORA1 (1.00) ADORA2AADORA1ADORA3TMIGD3KDM4E
SCHEMBL31695377 0.78 ESR2 (0.74) KDM4EGAAMAOAMAOBSTS
SCHEMBL18153397 0.78 ESR2 (0.74) KDM4EGAAMAOAMAOBSTS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0645382-B1 COUMARIN DERIVATIVE AND USE THEREOF MORINAGA MILK INDUSTRY CO LTD (JP) 2000-07-12 EP disclosed
US-5574062-A COMPOUNDS HAVE 3-ARYL AND 7-HYDROXY OR -ACYLOXY; USE TO INHIBIT 12-LIPOXYGENASE MORINAGA MILK INDUSTRY CO., LTD. (JP) 1996-11-12 US disclosed
EP-0645382-A1 COUMARIN DERIVATIVE AND USE THEREOF MORINAGA MILK INDUSTRY CO., LTD. (JP) 1995-03-29 EP disclosed