Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | BID | P55957 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076822 | 0.88 | AKR1B1 (0.58) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL24661354 | 0.88 | AKR1B1 (0.58) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL16312704 | 0.85 | ALDH1A1 (0.53) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL29588181 | 0.83 | HTR2A (0.58) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL28963713 | 0.83 | HTR2A (0.58) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL11544667 | 0.82 | AKR1B1 (0.55) | ADRA1AAKR1B1MAPTHPGDTDP1 | |
| SCHEMBL7821192 | 0.82 | AKR1B1 (0.74) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL29410826 | 0.81 | AKR1B1 (0.76) | ADRA1AAKR1B1MAPTHPGDGAA | |
| SCHEMBL30359 | 0.81 | AKR1B1 (0.76) | ADRA1AAKR1B1MAPTHPGDGAA | |
| SCHEMBL10533147 | 0.81 | AKR1B1 (0.53) | ADRA1AAKR1B1MAPTRXFP1BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136819-A | COMPOUNDS FOR ANTIINFLAMMATORY AGENTS OR CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM GMBH (DE) | 2000-10-24 | — | — | US | disclosed |
| EP-0736011-B1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM INT (DE) | 2000-07-26 | — | — | EP | disclosed |
| US-5968948-A | FOR TREATMENT OF EPILEPSY, STROKE, ALZHEIMER'S DISEASE, BRAIN DISEASES OR AS ANTIINFLAMMATORY OR ANTIPROLIFERATIVE AGENTS | BOERHINGER INGELHEIM GMBH (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5661157-A | Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations | BOEHRINGER INGELHEIM KG (DE) | 1997-08-26 | — | — | US | disclosed |
| WO-1995017389-A1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM KG (DE) | 1995-06-29 | — | — | WO | disclosed |