Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.54 |
| ▸ | KHK | P50053 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12208547 | 0.89 | BCL2A1 (0.53) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL4936462 | 0.89 | BCL2A1 (0.66) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL18013225 | 0.89 | BCL2A1 (0.66) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL8108416 | 0.85 | BCL2A1 (0.52) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL20158997 | 0.83 | KHK (0.49) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL12633649 | 0.82 | MAPT (0.52) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL8113241 | 0.82 | MAPT (0.52) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL8108460 | 0.82 | BCL2A1 (0.55) | BCL2A1KHKMAPTALDH1A1LMNA | |
| SCHEMBL8099622 | 0.81 | KHK (0.47) | BCL2A1KHKMAPTADRB1 | |
| SCHEMBL16218023 | 0.81 | KHK (0.47) | BCL2A1KHKMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |