SCHEMBL8108628

SCHEMBL8108628

COC(=O)c1ccc(NC(=O)C(NC(=O)OC(C)(C)C)c2ccc3c(c2)C(C)(C)CCC3(C)C)s1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 0.36
RARG P13631 6/20 0.36
RARA P10276 5/20 0.36
RXRA P19793 3/20 0.35
RXRB P28702 2/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
CYP3A4 P08684 5/20 0.35
CYP26A1 O43174 4/20 0.35
CYP26B1 Q9NR63 1/20 0.34
RXRG P48443 1/20 0.34
PPARG P37231 2/20 0.33
P2RY1 P47900 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
S1PR3 Q99500 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748606 0.94 RARB (0.40) RARBRARGRARARXRARXRB
SCHEMBL8100714 0.81 RARB (0.40) RARBRARGRARARXRARXRB
SCHEMBL8106311 0.80 RARB (0.37) RARBRARGRARARXRARXRB
SCHEMBL8106743 0.79 MEN1 (0.42) RARBRARGRARARXRARXRB
SCHEMBL8108607 0.78 RARB (0.35) RARBRARGRARARXRARXRB
SCHEMBL8757257 0.78 RARB (0.40) RARBRARGRARARXRARXRB
SCHEMBL8748829 0.77 RARB (0.55) RARBRARGRARARXRARXRB
SCHEMBL8100983 0.77 RARB (0.44) RARBRARGRARARXRARXRB
SCHEMBL8102431 0.76 RARB (0.43) RARBRARGRARARXRARXRB
SCHEMBL8093042 0.76 RORC (0.45) RARBRARGRARARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6165672-A Maleimide or alicyclic olefin-based monomers, copolymer resin of these monomers and photoresist using the resin HYUNDAI ELECTRONICS INDUSTRIES CO., LTD. (KR) 2000-12-26 US disclosed
US-6051243-A USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-04-18 US disclosed
US-5709867-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-01-20 US disclosed