Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045141 | 0.84 | ALOX5 (0.65) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL30142113 | 0.84 | ALOX5 (0.65) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL25895033 | 0.77 | ALOX5 (0.62) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL14665143 | 0.76 | ALOX5 (0.57) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL12223406 | 0.76 | ALOX5 (0.57) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL29473526 | 0.76 | ALOX5 (0.57) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL19608965 | 0.74 | DHFR (0.57) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL12364825 | 0.74 | ALOX5 (0.55) | ALOX5MAPTDHFRS1PR1S1PR3 | |
| SCHEMBL15987805 | 0.74 | TSHR (0.48) | MAPTALDH1A1MAPK1HPGDTSHR | |
| SCHEMBL5430836 | 0.73 | ALOX5 (0.57) | ALOX5MAPTDHFRS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |