Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTAFR | P25105 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479732 | 1.00 | MEN1 (0.52) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL8481421 | 1.00 | MEN1 (0.52) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL8477371 | 0.95 | CYP19A1 (0.50) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL6949036 | 0.92 | MEN1 (0.53) | MEN1KMT2AALDH1A1MAPK1CYP2D6 | |
| SCHEMBL8477891 | 0.91 | MEN1 (0.55) | MEN1KMT2AALDH1A1MMP12MAPK1 | |
| SCHEMBL7829883 | 0.90 | MEN1 (0.45) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL8552140 | 0.90 | MEN1 (0.45) | MEN1KMT2AALDH1A1MMP12CYP3A4 | |
| SCHEMBL7829887 | 0.90 | MEN1 (0.45) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL8482114 | 0.90 | NPC1 (0.48) | MEN1KMT2AALDH1A1MMP12MAPT | |
| SCHEMBL8476865 | 0.90 | MEN1 (0.45) | MEN1KMT2AALDH1A1MMP12CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037889-A1 | NOVEL COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-09-27 | — | — | EP | disclosed |
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| WO-1999029686-A1 | NOVEL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |