Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365007 | 1.00 | HTR1A (0.54) | HTR1ASLC6A4HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9091527 | 0.99 | HTR1A (0.53) | HTR1ASLC6A4HTR2AHTR2CHTR2B | |
| SCHEMBL9279214 | 0.86 | HTR7 (0.46) | HTR1AHTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8101143 | 0.83 | HTR1A (0.52) | HTR1AHTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8114352 | 0.83 | HTR1A (0.56) | HTR1ASLC6A4HTR2AHTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL9092334 | 0.83 | HTR1A (0.52) | HTR1AHTR2AHTR2CHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL9091771 | 0.82 | HTR1A (0.55) | HTR1ASLC6A4HTR2AHTR2CHTR7 | |
| SCHEMBL14359458 | 0.80 | HTR1A (0.55) | HTR1ASLC6A4HTR7MTNR1A | |
| SCHEMBL8114431 | 0.80 | HTR1A (0.53) | HTR1ASLC6A4HTR2AHTR2CHTR7 | |
| SCHEMBL14358972 | 0.79 | HTR1A (0.60) | HTR1ASLC6A4DRD2ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669331-B1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-10-11 | — | — | EP | claimed |
| US-5500443-A | SCHIZOPHRENIA | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | claimed |
| EP-0669331-A1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-08-30 | — | — | EP | claimed |
| US-20230035892-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | FLAGSHIP PIONEERING, INC. | 2023-02-02 | — | — | US | disclosed |
| US-11274158-B2 | Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators | FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) | 2022-03-15 | — | — | US | disclosed |
| EP-0669331-B1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-10-11 | — | — | EP | disclosed |
| EP-0669331-A1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-08-30 | — | — | EP | disclosed |