Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34471878 | 0.86 | PDE2A (0.41) | PDE2AAKT1AKT2 | |
| SCHEMBL2792621 | 0.83 | PDE2A (0.45) | PDE2ARAPGEF4TSHRAKR1C3AKR1C2 | |
| SCHEMBL530212 | 0.83 | ALDH1A1 (0.41) | RAPGEF4TSHRAKR1C3AKR1C2HSD11B1 | |
| SCHEMBL31499368 | 0.83 | ALDH1A1 (0.41) | RAPGEF4TSHRAKR1C3AKR1C2HSD11B1 | |
| SCHEMBL3951887 | 0.83 | ESR1 (0.40) | RAPGEF4TSHRAKR1C3AKR1C2HSD11B1 | |
| SCHEMBL16971901 | 0.81 | RAPGEF4 (0.37) | PDE2ARAPGEF4TSHRAKR1C3AKR1C2 | |
| SCHEMBL30271700 | 0.81 | RAPGEF4 (0.37) | PDE2ARAPGEF4TSHRAKR1C3AKR1C2 | |
| SCHEMBL2796185 | 0.80 | TSHR (0.56) | PDE2ATSHRAKT1AKT2 | |
| SCHEMBL1240276 | 0.80 | PDE2A (0.45) | PDE2AAKR1C3AKR1C2SLC6A3IDO1 | |
| SCHEMBL30326145 | 0.80 | PDE2A (0.46) | PDE2ATSHRHSD11B1MCL1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |