Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619442 | 0.90 | ROCK2 (0.46) | ROCK2ROCK1ERAP1RPS6KB1SMN1; SMN2 | |
| SCHEMBL6617981 | 0.90 | ROCK2 (0.46) | ROCK2ROCK1ERAP1RPS6KB1SMN1; SMN2 | |
| SCHEMBL6616873 | 0.87 | MKNK1 (0.43) | ROCK2ROCK1MKNK1RPS6KB1TSHR | |
| SCHEMBL6618548 | 0.87 | MKNK1 (0.43) | ROCK2ROCK1MKNK1RPS6KB1TSHR | |
| SCHEMBL8117078 | 0.79 | MKNK1 (0.38) | ROCK2ROCK1MKNK1RPS6KB1SMN1; SMN2 | |
| SCHEMBL6618464 | 0.75 | ROCK2 (0.49) | ROCK2ROCK1MKNK1RPS6KB1CDC7 | |
| SCHEMBL6618856 | 0.75 | ROCK2 (0.49) | ROCK2ROCK1MKNK1RPS6KB1CDC7 | |
| SCHEMBL6616216 | 0.74 | CYSLTR1 (0.46) | SMN1; SMN2MAPTTSHRCDC7GSK3B | |
| SCHEMBL6617440 | 0.74 | ROCK2 (0.49) | ROCK2ROCK1MKNK1RPS6KB1CDC7 | |
| SCHEMBL6617033 | 0.74 | ROCK2 (0.49) | ROCK2ROCK1MKNK1RPS6KB1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |