Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.49 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | MARK3 | P27448 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618856 | 1.00 | ROCK2 (0.49) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL8118257 | 0.94 | ROCK2 (0.46) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL6617033 | 0.88 | ROCK2 (0.49) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL6617440 | 0.88 | ROCK2 (0.49) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL6618548 | 0.85 | MKNK1 (0.43) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL6616873 | 0.85 | MKNK1 (0.43) | ROCK2GSK3BROCK1JAK2AURKB | |
| SCHEMBL6616216 | 0.82 | CYSLTR1 (0.46) | GSK3BCDK5DYRK1AFGFR1CDC7 | |
| SCHEMBL6615880 | 0.82 | CYSLTR1 (0.46) | GSK3BCDK5DYRK1AFGFR1CDC7 | |
| SCHEMBL6615711 | 0.80 | L3MBTL1 (0.39) | GSK3BCDK5DYRK1ACDK2FGFR1 | |
| SCHEMBL6616860 | 0.80 | L3MBTL1 (0.39) | GSK3BCDK5DYRK1ACDK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |