Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ranitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.98 |
| ▸ | RAD52 | P43351 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | ACHE | P22303 | 15/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | ATP4A | P20648 | 1/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ranitidine SCHEMBL8110889 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL33299 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL33298 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8819146 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL2228178 | 0.99 | RAD52 (0.98) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL824 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8594797 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8796367 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL825 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL826 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855835-B2 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2005-02-15 | — | — | US | claimed |
| US-20040048922-A1 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2004-03-11 | — | — | US | claimed |
| WO-2020239685-A1 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING UVEAL MELANOMA | UNIVERSITEIT GENT (BE) | 2020-12-03 | — | — | WO | disclosed |
| US-8471011-B2 | Preparation of acid addition salts of amine bases by solid phase—gas phase reactions | APOTEX PHARMACHEM INC. (CA) | 2013-06-25 | — | — | US | disclosed |
| US-20060205944-A1 | Preparation of acid addition salts of amine bases by solid phase-gas phase reactions | APOTEX PHARMACHEM INC. | 2006-09-14 | — | — | US | disclosed |
| US-6855835-B2 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2005-02-15 | — | — | US | disclosed |
| US-6855835-B2 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2005-02-15 | — | — | US | disclosed |
| US-20040267030-A1 | Novel process for the preparation of form 1 ranitidine hydrochloride | AVENTIS PHARMACEUTICALS INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040048922-A1 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2004-03-11 | — | — | US | disclosed |
| US-20040048922-A1 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | PHARMEXCEL SRL (IT) | 2004-03-11 | — | — | US | disclosed |
| EP-1265879-A1 | ALLOMORPH ISOMER Z HYDROCHLORIDE OF RANITIDINE | Pharmexcel SRL (IT) | 2002-12-18 | — | — | EP | disclosed |
| US-20020151729-A1 | Novel process for the preparation of form 1 ranitidine hydrochloride | CHENG WEN J (US) | 2002-10-17 | — | — | US | disclosed |
| WO-2001064662-A1 | ALLOMORPH ISOMER Z HYDROCHLORIDE OF RANITIDINE | PHARMEXCEL SRL (IT) | 2001-09-07 | — | — | WO | disclosed |
| US-4968808-A | MULTISTEP IN ONE POT | HEUMANN PHARMA GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0219225-B1 | PROCESS FOR THE PREPARATION OF RANITIDINE OR ACID ADDITION SALTS THEREOF, AND INTERMEDIATES FOR THIS PREPARATION | A/S GEA Farmaceutisk Fabrik (DK) | 1989-02-22 | — | — | EP | disclosed |
| US-4279819-A | GASTROINTESTINAL DISORDERS | ALLEN & HANBURYS LTD. (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4255440-A | ANTIALLERGENS, ANTIULCER AGENTS | ALLEN & HANBURYS LIMITED (GB) | 1981-03-10 | — | — | US | disclosed |
| US-4169855-A | ANTIHISTAMINES, ANTISECRETORY AGENTS | Allen & Hansbury, Limited (GB) | 1979-10-02 | — | — | US | disclosed |
| US-4128658-A | HISTAMINE ANTAGONISTS | ALLEN & HANBURYS LIMITED (GB) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205944-A1 | Preparation of acid addition salts of amine bases by solid phase-gas phase reactions | POLR2A, AVPR1B, AVPR2 | HRH2 12/4885RAD52 4397/4885MAPT 314/4885 |
| US-20040048922-A1 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative | SHBG, NR5A1, OPRM1 | HRH2 3536/4885RAD52 2696/4885MAPT 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.