Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.69 |
| ▸ | CTSB | P07858 | 12/20 | 0.69 |
| ▸ | CTSS | P25774 | 10/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757161 | 1.00 | CTSK (0.69) | CTSKCTSBCTSSKCNH2CTSL | |
| SCHEMBL4789866 | 0.92 | CTSK (0.70) | CTSKCTSBCTSSKCNH2CTSL | |
| SCHEMBL4789293 | 0.83 | CTSK (0.68) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8106184 | 0.83 | CTSK (0.68) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8105437 | 0.83 | CTSK (0.55) | CTSKCTSBCTSSKCNH2CTSL | |
| SCHEMBL2243635 | 0.83 | CTSK (0.55) | CTSKCTSBCTSSKCNH2CTSL | |
| SCHEMBL14642363 | 0.83 | CTSK (0.55) | CTSKCTSBCTSSKCNH2CTSL | |
| SCHEMBL8108547 | 0.83 | CTSK (0.67) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8100198 | 0.83 | CTSK (0.69) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL4787930 | 0.83 | CTSK (0.69) | CTSKCTSBCTSSKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001128-A1 | 1,2-CYCL0HEXANE DICARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |