Tetrahydrofuran

Tetrahydrofuran

SCHEMBL8112484

C1CCOC1.CCC(=O)CC

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.56
ALDH1A1 P00352 4/20 0.44
TSHR P16473 2/20 0.35
HTT P42858 1/20 0.35
POLB P06746 3/20 0.34
LMNA P02545 1/20 0.34
FFAR3 O14843 1/20 0.33
RECQL P46063 1/20 0.32
GLA P06280 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
RAB9A P51151 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MEN1 O00255 1/20 0.31
TP53 P04637 1/20 0.31
KMT2A Q03164 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11782029 0.97 TDP1 (0.53) TDP1ALDH1A1TSHRHTTPOLB
Dioxane SCHEMBL11782030 0.88 TDP1 (0.62) TDP1ALDH1A1TSHRHTTPOLB
SCHEMBL28308950 0.84 TDP1 (0.50) TDP1ALDH1A1TSHRFFAR3
Propionic Acid SCHEMBL28145772 0.83 FFAR3 (0.56) TDP1ALDH1A1TSHRHTTLMNA
Tetrahydrofuran SCHEMBL27415023 0.83 FFAR3 (0.56) TDP1ALDH1A1TSHRHTTLMNA
Tetrahydrofuran SCHEMBL442775 0.83 ALDH1A1 (0.56) TDP1ALDH1A1TSHRHTTPOLB
Tetrahydrofuran SCHEMBL28279972 0.83 ALDH1A1 (0.56) TDP1ALDH1A1TSHRHTTPOLB
Tetrahydrofuran SCHEMBL18862833 0.81 ALDH1A1 (0.53) TDP1ALDH1A1TSHRHTTPOLB
Butanone SCHEMBL2962461 0.81 ALDH1A1 (0.53) TDP1ALDH1A1TSHRHTTPOLB
Tetrahydrofuran SCHEMBL28295154 0.81 ALDH1A1 (0.53) TDP1ALDH1A1TSHRHTTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105283527-B Photonasty hydrophilic coating 英派尔科技开发有限公司 2018-05-29 CN disclosed
CN-107530617-A Hygroscopic material and its manufacture method and packaging material 富士胶片株式会社 2018-01-02 CN disclosed
EP-1025074-A1 RECOVERY AND RECYCLE OF CATALYST COMPONENTS USED IN PALLADIUM-CATALYZED PREPARATION OF ARYLCARBOXYLIC ACIDS ALBEMARLE CORPORATION (US) 2000-08-09 EP disclosed
US-6096920-A LARGE-SCALE PRODUCTION OF CERTAIN AROMATICALLY-SUBSTITUTED ALIPHATIC CARBOXYLIC ACIDS AND THEIR ACID DERIVATIVES ALBEMARLE CORPORATION (US) 2000-08-01 US disclosed
WO-1999019289-A1 RECOVERY AND RECYCLE OF CATALYST COMPONENTS USED IN PALLADIUM-CATALYZED PREPARATION OF ARYLCARBOXYLIC ACIDS ALBEMARLE CORPORATION (US) 1999-04-22 WO disclosed