Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MYB | P10242 | 11/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111856 | 0.87 | POLB (0.73) | MAPK1MYBPOLBRAB9AKDM4E | |
| SCHEMBL4324927 | 0.85 | MYB (0.72) | HSD17B10MAPK1MYBPOLBRAB9A | |
| SCHEMBL8117453 | 0.85 | MAPT (0.52) | HSD17B10MYBPOLBRAB9AKDM4E | |
| SCHEMBL8118633 | 0.84 | POLB (0.77) | HSD17B10MAPK1MYBPOLBRAB9A | |
| SCHEMBL8538963 | 0.83 | MYB (0.80) | MYBRAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL31237961 | 0.83 | MYB (0.80) | MYBRAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL8112822 | 0.82 | MYB (0.58) | HSD17B10MYBPOLBRAB9AKDM4E | |
| SCHEMBL4319288 | 0.81 | TUBB4A (0.67) | MYBPOLBRAB9ANPC1 | |
| SCHEMBL8117263 | 0.81 | MYB (0.61) | HSD17B10MAPK1MYBPOLBRAB9A | |
| SCHEMBL4425533 | 0.81 | MAPK1 (0.57) | HSD17B10MAPK1MYBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004584-A2 | Pyranoquinoline derivatives as inhibitors of cell proliferation | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| US-5434160-A | Autoimmune diseases; prevention of excess cell proliferation or enzyme release | LILLY INDUSTRIES LIMITED (GB) | 1995-07-18 | — | — | US | disclosed |
| EP-0599514-A2 | Pyranoquinoline derivatives as inhibitors of cell proliferation | LILLY INDUSTRIES LIMITED (GB) | 1994-06-01 | — | — | EP | disclosed |