Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 3/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862028 | 0.87 | P4HB (0.49) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2862027 | 0.87 | P4HB (0.49) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2862023 | 0.87 | P4HB (0.49) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL32688029 | 0.81 | TDP1 (0.52) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8809121 | 0.81 | P4HB (0.44) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8809116 | 0.81 | P4HB (0.44) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21457237 | 0.81 | UNG (0.58) | P4HBEGFRTDP1ALDH1A1KDM4E | |
| SCHEMBL6841774 | 0.81 | ALDH1A1 (0.59) | EGFRTDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL2853921 | 0.79 | P4HB (0.57) | P4HBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2853918 | 0.79 | P4HB (0.57) | P4HBGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004584-A2 | Pyranoquinoline derivatives as inhibitors of cell proliferation | ELI LILLY AND COMPANY LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5434160-A | Autoimmune diseases; prevention of excess cell proliferation or enzyme release | LILLY INDUSTRIES LIMITED (GB) | 1995-07-18 | — | — | US | disclosed |
| EP-0599514-A2 | Pyranoquinoline derivatives as inhibitors of cell proliferation | LILLY INDUSTRIES LIMITED (GB) | 1994-06-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |