Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.73 |
| ▸ | EGFR | P00533 | 6/20 | 0.73 |
| ▸ | ABL1 | P00519 | 4/20 | 0.73 |
| ▸ | ABL2 | P42684 | 4/20 | 0.73 |
| ▸ | IGF1R | P08069 | 9/20 | 0.71 |
| ▸ | INSR | P06213 | 5/20 | 0.69 |
| ▸ | LYN | P07948 | 4/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.69 |
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.69 |
| ▸ | FLT4 | P35916 | 3/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
| ▸ | AURKA | O14965 | 2/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.69 |
| ▸ | CSF1R | P07333 | 2/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.69 |
| ▸ | MARK3 | P27448 | 2/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.69 |
| ▸ | BLK | P51451 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11350290 | 0.90 | IGF1R (0.77) | SRCEGFRABL1ABL2IGF1R | |
| SCHEMBL7018931 | 0.90 | IGF1R (0.69) | SRCEGFRABL1ABL2IGF1R | |
| SCHEMBL8108104 | 0.89 | SRC (0.91) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL27469030 | 0.89 | IGF1R (0.72) | SRCEGFRABL1ABL2IGF1R | |
| SCHEMBL8098919 | 0.88 | SRC (0.90) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8098935 | 0.87 | SRC (0.90) | SRCEGFRABL1ABL2IGF1R | |
| SCHEMBL8098846 | 0.85 | SRC (0.75) | SRCEGFRABL1ABL2IGF1R | |
| SCHEMBL6462070 | 0.85 | SRC (0.78) | SRCEGFRABL1ABL2INSR | |
| SCHEMBL30054291 | 0.85 | SRC (0.78) | SRCEGFRABL1ABL2INSR | |
| SCHEMBL8108111 | 0.84 | SRC (1.00) | SRCEGFRABL1ABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |