SCHEMBL8113643

SCHEMBL8113643

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2nc(C)ccc2N(C)S(C)(=O)=O)n1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.53
CDK1 P06493 1/20 0.47
CYP1A2 P05177 1/20 0.40
MAPT P10636 3/20 0.39
TP53 P04637 1/20 0.39
GLA P06280 1/20 0.39
KMT2A Q03164 2/20 0.37
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL732548 0.84 GAA (0.52) GAACDK1CYP1A2MAPTTP53
SCHEMBL8855127 0.83 GAA (0.46) GAACDK1MAPTTP53GLA
SCHEMBL9718364 0.83 CDK1 (0.63) GAACDK1CYP1A2MAPTTP53
SCHEMBL15449146 0.83 GAA (0.57) GAACDK1CYP1A2MAPTTP53
SCHEMBL54922 0.76 GAA (0.58) GAACDK1CYP1A2MAPTTP53
SCHEMBL8347834 0.76 GAA (0.58) GAACDK1CYP1A2MAPTTP53
SCHEMBL2320176 0.75 GAA (0.57) GAACDK1CYP1A2MAPTTP53
SCHEMBL8855373 0.75 GAA (0.50) GAACDK1CYP1A2MAPTTP53
SCHEMBL8855289 0.74 ALOX15 (0.42) GAAMAPTTP53KMT2ATSHR
SCHEMBL8675183 0.74 GAA (0.55) GAACDK1CYP1A2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0451468-B2 Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production ISHIHARA SANGYO KAISHA (JP) 2000-03-08 EP claimed
EP-0451468-B2 Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production ISHIHARA SANGYO KAISHA (JP) 2000-03-08 EP disclosed
US-5139565-A Herbicides which are safe for corn ISHIHARA SANGYO KAISHA LTD. (JP) 1992-08-18 US disclosed
EP-0451468-A1 Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production ISHIHARA SANGYO KAISHA, LTD. (JP) 1991-10-16 EP disclosed