SCHEMBL732548

SCHEMBL732548

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ncccc2N(C)S(C)(=O)=O)n1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.52
CDK1 P06493 1/20 0.46
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
GLA P06280 1/20 0.40
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 3/20 0.39
TRPV1 Q8NER1 1/20 0.37
MEN1 O00255 1/20 0.36
HSD17B10 Q99714 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
PTK2 Q05397 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8855127 0.94 GAA (0.46) GAACDK1MAPTTP53GLA
SCHEMBL8675183 0.91 GAA (0.55) GAACDK1MAPTTP53GLA
SCHEMBL8855373 0.90 GAA (0.50) GAACDK1MAPTTP53GLA
SCHEMBL8876516 0.88 GAA (0.51) GAACDK1MAPTTP53GLA
SCHEMBL8855192 0.87 GAA (0.49) GAACDK1MAPTTP53GLA
SCHEMBL8855289 0.86 ALOX15 (0.42) GAAMAPTTP53KMT2ATRPV1
SCHEMBL9418679 0.85 GAA (0.48) GAACDK1MAPTTP53GLA
SCHEMBL8113643 0.84 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL9433158 0.84 KMT2A (0.39) GAATP53KMT2ATRPV1MEN1
SCHEMBL20534922 0.83 GAA (0.51) GAACDK1MAPTTP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2836072-A1 HERBICIDAL COMPOSITION COMPRISING URACIL COMPOUND AS ACTIVE INGREDIENT Dongbu Farm Hannong Co., Ltd. (KR) 2015-02-18 EP claimed
US-20150024940-A1 HERBICIDAL COMPOSITION COMPRISING URACIL COMPOUND AS ACTIVE INGREDIENT DONGBU FARM HANNONG CO., LTD. (KR) 2015-01-22 US claimed
WO-2013154396-A1 HERBICIDAL COMPOSITION COMPRISING URACIL COMPOUND AS ACTIVE INGREDIENT DONGBU FARM HANNONG CO., LTD. (KR) 2013-10-17 WO claimed
US-20100261680-A1 HERBICIDES CONTAINING SUBSTITUTED THIEN-3-YL-SULPHONYLAMINO(THIO)CARBONYL-TRIAZOLIN(ETHI)ONES BAYER CROPSCIENCE AG (DE) 2010-10-14 US claimed
US-20050192182-A1 Herbicidal mixtures based on substituted aryl ketones BAYER CROPSCIENCE AG (DE) 2005-09-01 US claimed
US-20050090396-A1 Herbicides based on substituted carboxylic acid anilides BAYER CROPSCIENCE AG (DE) 2005-04-28 US claimed
US-20050003963-A1 Herbicides containing substituted thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2005-01-06 US claimed
US-20040171488-A1 N-aryl-uracils based Herbicides FEUCHT DIETER (DE) 2004-09-02 US claimed
EP-1429612-A1 HERBICIDES CONTAINING SUBSTITUTED THIEN-3-YL-SULFONYLAMINO(THIO)CARBONYL-TRIAZOLIN(THI)ONE Bayer CropScience AG (DE) 2004-06-23 EP claimed
US-20040116294-A1 Herbicides based on substituted aryl ketones BAYER CROPSCIENCE AG (DE) 2004-06-17 US claimed
EP-1278413-A2 N-ARYL-URACILE-BASED HERBICIDES Bayer CropScience AG (DE) 2003-01-29 EP claimed
EP-1233672-A2 SYNERGISTIC HERBICIDAL ACTIVE SUBSTANCE COMBINATIONS Bayer Aktiengesellschaft (DE) 2002-08-28 EP claimed
EP-1221844-A2 SELECTIVE HERBICIDES BASED ON PYRIMIDINE-DERIVATIVES Bayer Aktiengesellschaft (DE) 2002-07-17 EP claimed
WO-2001039597-A2 N-ARYL-URACILE-BASED HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-06-07 WO claimed
WO-2001035741-A2 SYNERGISTIC HERBICIDAL ACTIVE SUBSTANCE COMBINATIONS BAYER AKTIENGESELLSCHAFT (DE) 2001-05-25 WO claimed
WO-2001035740-A2 SELECTIVE HERBICIDES BASED UPON 2,6-DISUBSTITUTED PYRIDINE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2001-05-25 WO claimed
WO-2001024633-A2 SELECTIVE HERBICIDES BASED ON PYRIMIDINE-DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2001-04-12 WO claimed
EP-0451468-B2 Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production ISHIHARA SANGYO KAISHA (JP) 2000-03-08 EP claimed
US-5536698-A Crop-protecting compositions containing isoxazolines or isothiazdines, novel isoxazolines, and their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1996-07-16 US claimed
US-5488027-A Herbicide-safener combinations containing sulfonylurea or imidazolinone herbicides HOECHST AKTIENGESELLSCHAFT (DE) 1996-01-30 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192182-A1 Herbicidal mixtures based on substituted aryl ketones DDT, CBR3, CYP1B1 GAA 690/4885CDK1 1685/4885MAPT 3584/4885
US-20050090396-A1 Herbicides based on substituted carboxylic acid anilides AADAC, NOTUM, NAAA GAA 326/4885CDK1 1989/4885MAPT 3894/4885
US-20150024940-A1 HERBICIDAL COMPOSITION COMPRISING URACIL COMPOUND AS ACTIVE INGREDIENT UNG, DDT, HDHD5 GAA 188/4885CDK1 1831/4885MAPT 2234/4885
US-20050003963-A1 Herbicides containing substituted thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one DDT, TARS2, CBR3 GAA 1644/4885CDK1 538/4885MAPT 3865/4885
US-20040171488-A1 N-aryl-uracils based Herbicides DDT, UNG, DDC GAA 298/4885CDK1 1832/4885MAPT 3439/4885
US-20100261680-A1 HERBICIDES CONTAINING SUBSTITUTED THIEN-3-YL-SULPHONYLAMINO(THIO)CARBONYL-TRIAZOLIN(ETHI)ONES DDT, TARS2, TST GAA 1609/4885CDK1 1848/4885MAPT 2870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.