Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8123737 | 0.86 | ALDH1A1 (0.42) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8123913 | 0.81 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL8130034 | 0.79 | MAPT (0.42) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8122081 | 0.77 | ALDH1A1 (0.42) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8149239 | 0.73 | GAA (0.35) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8578786 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL8127824 | 0.70 | KCNH2 (0.39) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8124757 | 0.70 | ALDH1A1 (0.39) | KDM4EALDH1A1GAANPC1GLA | |
| SCHEMBL8124327 | 0.65 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL8607073 | 0.64 | KDM4E (0.49) | KDM4EALDH1A1GAANPC1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | claimed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | claimed |
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5935956-A | Pyridazine compounds | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-08-10 | — | — | US | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |