Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124654 | 0.92 | APP (0.36) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL8130034 | 0.90 | MAPT (0.42) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL8124757 | 0.82 | ALDH1A1 (0.39) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL8121408 | 0.80 | TRPM8 (0.38) | — | |
| SCHEMBL8123737 | 0.79 | ALDH1A1 (0.42) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL8123913 | 0.76 | KDM4E (0.44) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL10365809 | 0.75 | ACHE (0.38) | GAAKDM4ENPC1ALDH1A1GLA | |
| Bromide SCHEMBL8164605 | 0.74 | ITGB3 (0.33) | — | |
| SCHEMBL9866597 | 0.74 | PBRM1 (0.37) | GAAKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL8124342 | 0.74 | ALDH1A1 (0.39) | GAAKDM4ENPC1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |