Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830020 | 0.88 | TOP2A (0.61) | TOP2ANLRP3USP2HSD17B10ALDH1A1 | |
| SCHEMBL8115908 | 0.86 | TOP2A (0.51) | TOP2ANLRP3ALDH1A1 | |
| SCHEMBL17145910 | 0.82 | TOP2A (0.54) | TOP2ANLRP3USP2HSD17B10GAA | |
| SCHEMBL2313196 | 0.82 | TOP2A (0.54) | TOP2ANLRP3USP2HSD17B10ALDH1A1 | |
| SCHEMBL9830253 | 0.81 | NLRP3 (0.59) | TOP2ANLRP3USP2HSD17B10GAA | |
| SCHEMBL9830404 | 0.81 | MAPT (0.56) | TOP2ANLRP3GAADHODHALDH1A1 | |
| SCHEMBL11311241 | 0.80 | TOP2A (0.63) | TOP2ANLRP3USP2HSD17B10CYP3A4 | |
| SCHEMBL11138734 | 0.78 | TOP2A (0.59) | TOP2ANLRP3GAAALDH1A1 | |
| SCHEMBL2311231 | 0.77 | MAPT (0.50) | TOP2ANLRP3GAAALDH1A1 | |
| SCHEMBL3668564 | 0.77 | TOP2A (0.58) | TOP2ANLRP3HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |