Sugi Predict

Sugi Predict / Compounds / SCHEMBL8115457

SCHEMBL8115457

SCHEMBL8115457

CC(C)(C)C(=O)NS(N)(=O)=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 5/20 0.42
▸ CA2 P00918 5/20 0.42
▸ CA9 Q16790 3/20 0.42
▸ CA7 P43166 2/20 0.42
▸ CA14 Q9ULX7 2/20 0.42
▸ CA12 O43570 2/20 0.42
▸ CA4 P22748 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ CYP1A2 P05177 1/20 0.30
▸ PKM P14618 1/20 0.30
▸ PTK2B Q14289 1/20 0.30
▸ ABCC9 O60706 1/20 0.30
▸ ABCC8 Q09428 1/20 0.30
▸ KCNJ11 Q14654 1/20 0.30
▸ PDK1 Q15118 1/20 0.30
▸ PDK2 Q15119 1/20 0.30
▸ PDK3 Q15120 1/20 0.30
▸ KCNJ8 Q15842 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14679343 0.77 CA14 (0.33) CA1CA2CA9CA7CA14
SCHEMBL92831 0.76 PPARA (0.43) CA1CA2CA9CA7CA14
SCHEMBL16051165 0.76 ALDH1A1 (0.38) CA1CA2CA9CA7CA14
SCHEMBL24178088 0.74 ALDH1A1 (0.36) CA1CA2CA9CA7CA14
SCHEMBL19627394 0.72 ALDH1A1 (0.35) CA1CA2CA9CA7CA14
SCHEMBL6308658 0.72 ALDH1A1 (0.35) CA1CA2CA9CA7CA14
SCHEMBL15195118 0.72 CA14 (0.39) CA1CA2CA9CA7CA14
SCHEMBL24178069 0.70 ALDH1A1 (0.34) CA1CA2CA9CA7CA14
SCHEMBL26770872 0.70 ALDH1A1 (0.34) CA1CA2CA9CA7CA14
SCHEMBL24178124 0.70 ALDH1A1 (0.34) CA1CA2CA9CA7CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220396551-A1 EBNA1 Inhibitors and Their Method of Use WISTAR INST (US) 2022-12-15 — — US disclosed
US-20170334894-A1 Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof ENANTA PHARMACEUTICALS, INC. 2017-11-23 — — US disclosed
US-20170334894-A1 Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof ENANTA PHARMACEUTICALS, INC. 2017-11-23 — — US disclosed
US-20070293530-A1 SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS METHYLGENE INC. (CA) 2007-12-20 — — US disclosed
US-20070293530-A1 SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS METHYLGENE INC. (CA) 2007-12-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170334894-A1 Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof SLC10A1, FXR1, NR1H4 CA1 2031/4885CA2 1683/4885CA9 2564/4885
US-20070293530-A1 SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC11, HAT1 CA1 227/4885CA2 303/4885CA9 261/4885
US-20220396551-A1 EBNA1 Inhibitors and Their Method of Use EBNA1BP2, MLLT1, PML CA1 3628/4885CA2 3767/4885CA9 2302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.