Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 13/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 13/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 13/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 13/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 7/20 | 0.35 |
| ▸ | GRIK4 | Q16099 | 7/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117314 | 0.84 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8119017 | 0.84 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8107468 | 0.79 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8180598 | 0.75 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8114495 | 0.74 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8109569 | 0.74 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8092046 | 0.73 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8341491 | 0.73 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8098704 | 0.70 | GRIA1 (0.37) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8345928 | 0.69 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664802-B1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 2000-03-15 | — | — | EP | disclosed |