Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 9/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448878 | 0.85 | GAA (0.56) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL7453786 | 0.81 | GAA (0.56) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL8112152 | 0.79 | GAA (0.41) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL7444939 | 0.75 | GAA (0.44) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL7444647 | 0.74 | GAA (0.51) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL7436974 | 0.71 | GAA (0.44) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL7400198 | 0.70 | CHRM1 (0.34) | GAASIGMAR1MEN1KMT2AHTR3A | |
| SCHEMBL4958523 | 0.67 | GAA (0.68) | GAASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL4958510 | 0.64 | HTR3A (0.50) | GAASMN1; SMN2SIGMAR1HTR3ACHRNA7 | |
| SCHEMBL14411936 | 0.64 | GRIN1 (0.47) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711299-B1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5637596-A | REACTING AMINOMETHYLINDOLE DERIVATIVE WITH A CARBONYL CONTAINING CYCLIZING AGENT; 5-HT3 RECEPTOR ATAGONIST; USEFUL FOR TREATING ANXIETY, PSYCHOSIS, GUT MOTILITY DISORDER, EMESIS, MIGRAINE AND DRUG ADDICTION | PHARMACIA S.P.A. (IT) | 1997-06-10 | — | — | US | disclosed |