Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 8/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | HTR1D | P28221 | 6/20 | 0.39 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109212 | 0.90 | HTR1F (0.47) | HTR1FMCHR1PTGDR2HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL8580575 | 0.74 | HTR1F (0.43) | HTR1FMCHR1PTGDR2HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL8700695 | 0.72 | HASPIN (0.41) | HTR1FMCHR1PTGDR2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8604554 | 0.70 | HTR1F (0.41) | HTR1FMCHR1HTR1AHTR1DHTR1B | |
| SCHEMBL7656378 | 0.69 | ALOX5 (0.36) | — | |
| Hydrochloric Acid SCHEMBL7659300 | 0.68 | ALOX5 (0.36) | — | |
| SCHEMBL8117021 | 0.65 | HTR1F (0.69) | HTR1FMCHR1HTR1AHTR1DHTR1B | |
| SCHEMBL7662558 | 0.65 | HTR1F (0.67) | HTR1FHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7666106 | 0.64 | HTR1F (0.66) | HTR1FHTR1AHTR1DHTR1B | |
| SCHEMBL7477474 | 0.64 | HTR1D (0.75) | HTR1FHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749962-B1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | LILLY CO ELI (US) | 2000-11-02 | — | — | EP | disclosed |
| US-5814653-A | SUMATRIPTAN FOR RELIEF OF MIGRAINE PAIN AND OTHER DISORDERS ASSOCIATED WITH PEPTIDE EXTRAVASATION DIE TO STUMULATION OF THE TRIGEMINAL GANGLIA; 5-HT 1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0749962-A1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |