Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 13/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CTSB | P07858 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731538 | 0.93 | MAPT (0.67) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3189942 | 0.93 | MAPT (0.67) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29777337 | 0.80 | MAPT (0.67) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5188552 | 0.80 | MAPT (0.67) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10204048 | 0.78 | PDE10A (0.71) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28350444 | 0.77 | PDE10A (0.65) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL949962 | 0.76 | PDE10A (1.00) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29651350 | 0.76 | MAPT (0.69) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11766895 | 0.76 | MAPT (0.69) | PDE10AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL196509 | 0.76 | LMNA (0.64) | PDE10AMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |