Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 15/20 | 0.62 |
| ▸ | PGK1 | P00558 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395817 | 0.84 | PDGFRB (0.58) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL24614203 | 0.77 | PDGFRB (0.60) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL3908370 | 0.77 | PDGFRB (1.00) | PDGFRBPDGFRAPGK1EGFRLCK | |
| SCHEMBL3389455 | 0.76 | PDGFRB (0.55) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL24894766 | 0.76 | PDGFRB (0.59) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL3884081 | 0.74 | PDGFRB (0.47) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL30223495 | 0.73 | KDM4E (0.70) | PDGFRBPDGFRAEGFRLCKALDH1A1 | |
| SCHEMBL29338738 | 0.72 | PDGFRB (0.71) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL3908347 | 0.72 | PDGFRB (0.75) | PDGFRBPDGFRAPGK1EGFRINSR | |
| SCHEMBL12844007 | 0.71 | ALDH1A1 (0.50) | PDGFRBPDGFRAPGK1EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001946-A4 | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56?1ck TYROSINE KINASES | RHONE POULENC RORER PHARMA (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-1001946-A1 | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56?1ck TYROSINE KINASES | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1998054157-A1 | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p561ck TYROSINE KINASES | RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | disclosed |