Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481104 | 0.88 | PTAFR (0.49) | PTAFRALDH1A1LMNATP53NPC1 | |
| SCHEMBL8480926 | 0.88 | EPHX1 (0.51) | PTAFRALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL8477406 | 0.88 | GPR132 (0.50) | PTAFRMAPK1MEN1KMT2APRMT5 | |
| SCHEMBL8553957 | 0.88 | GPR132 (0.50) | PTAFRMAPK1MEN1KMT2APRMT5 | |
| SCHEMBL8479935 | 0.87 | PTAFR (0.49) | PTAFRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8482057 | 0.87 | PRKCI (0.46) | PTAFRCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8551987 | 0.87 | PRKCI (0.46) | PTAFRCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8477371 | 0.86 | CYP19A1 (0.50) | PTAFRCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8481421 | 0.86 | MEN1 (0.52) | PTAFRCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8479732 | 0.86 | MEN1 (0.52) | PTAFRCYP3A4CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037889-A1 | NOVEL COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-09-27 | — | — | EP | disclosed |
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| WO-1999029686-A1 | NOVEL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |