Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 1/20 | 0.71 |
| ▸ | NQO1 | P15559 | 3/20 | 0.61 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | BLM | P54132 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | NSD2 | O96028 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ametantrone SCHEMBL29723071 | 0.83 | TOP2B (1.00) | TOP2BNQO1FTOMEN1KMT2A | |
| Ametantrone SCHEMBL3344151 | 0.83 | TOP2B (1.00) | TOP2BNQO1FTOMEN1KMT2A | |
| SCHEMBL18567075 | 0.83 | NQO1 (0.86) | TOP2BNQO1FTOMEN1KMT2A | |
| SCHEMBL32690213 | 0.83 | NQO1 (0.86) | TOP2BNQO1FTOMEN1KMT2A | |
| SCHEMBL18567079 | 0.83 | TOP2B (0.86) | TOP2BNQO1FTOMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11041980 | 0.82 | TOP2B (0.97) | TOP2BNQO1FTOMEN1KMT2A | |
| Mitoxantrone SCHEMBL187688 | 0.79 | MEN1 (0.84) | TOP2BNQO1FTOMEN1KMT2A | |
| Mitoxantrone SCHEMBL28175576 | 0.78 | MEN1 (0.84) | TOP2BNQO1FTOMEN1KMT2A | |
| Ametantrone SCHEMBL4022 | 0.77 | TOP2B (0.86) | TOP2BNQO1FTOMEN1KMT2A | |
| Ametantrone SCHEMBL31237396 | 0.77 | TOP2B (0.86) | TOP2BNQO1FTOMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0981528-A1 | REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 2000-03-01 | — | — | EP | disclosed |
| WO-1998049172-A1 | REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY | UNIVERSITY OF VERMONT (US) | 1998-11-05 | — | — | WO | disclosed |