Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141814 | 0.88 | CDK8 (0.49) | TAAR1CDK8LOXL2CHEK1NOS3 | |
| SCHEMBL27521486 | 0.82 | KARS1 (0.44) | TAAR1CDK8CHEK1NOS3NOS1 | |
| SCHEMBL7812451 | 0.82 | CDK8 (0.47) | TAAR1CDK8CHEK1NOS3NOS1 | |
| SCHEMBL26463821 | 0.81 | KDM4E (0.44) | TAAR1EGFRCDC7PIM1GSK3B | |
| Hydrochloric Acid SCHEMBL7808217 | 0.81 | NOS3 (0.44) | TAAR1CDK8CHEK1NOS3NOS1 | |
| SCHEMBL27566670 | 0.81 | TAAR1 (0.53) | TAAR1CDK8LOXL2SGK1KDM4E | |
| SCHEMBL7803222 | 0.79 | NPC1 (0.42) | CDK8KDM4EMEN1KMT2AMAOB | |
| SCHEMBL7141855 | 0.79 | KDM4E (0.45) | ALOX5KDM4EMEN1MAPTKMT2A | |
| SCHEMBL26110507 | 0.79 | KDM4E (0.45) | ALOX5KDM4EMEN1MAPTKMT2A | |
| SCHEMBL15029205 | 0.78 | MAPK1 (0.42) | ALOX5CDC7PIM1GSK3BHIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996443-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-05-03 | — | — | EP | claimed |
| WO-1999001128-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-14 | — | — | WO | claimed |