Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130431 | 0.91 | HTT (0.56) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL8130436 | 0.91 | HTT (0.56) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL8130426 | 0.91 | HTT (0.56) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL25487774 | 0.81 | SIRT1 (0.46) | — | |
| SCHEMBL29045163 | 0.81 | HTT (0.63) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL16574785 | 0.80 | HTT (0.62) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL14537422 | 0.80 | HTT (0.52) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL10705410 | 0.79 | HTT (0.60) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL1586583 | 0.79 | DPP8 (0.61) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL10798142 | 0.79 | FAAH (0.46) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680469-B1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-04-26 | — | — | EP | disclosed |