Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | F9 | P00740 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911248 | 0.85 | MAOB (0.52) | MAOBCYP11B1CYP19A1F9F10 | |
| SCHEMBL4260225 | 0.83 | MAOB (0.77) | MAOBMAOAMRGPRX4 | |
| SCHEMBL8133729 | 0.81 | CYP19A1 (0.47) | MAOBCYP19A1GPR132MRGPRX4 | |
| SCHEMBL8807332 | 0.78 | CYP19A1 (0.52) | CYP11B1CYP19A1GPR132MRGPRX4 | |
| SCHEMBL28048524 | 0.77 | MAPK1 (0.64) | CYP11B1CYP19A1F9F10GPR132 | |
| SCHEMBL22964344 | 0.77 | MAPK1 (0.58) | F9F10GPR132MAPK1 | |
| SCHEMBL8119668 | 0.76 | — | — | |
| SCHEMBL28011530 | 0.76 | MAPK1 (0.64) | MAOBF9F10GPR132MAPK1 | |
| SCHEMBL8131362 | 0.76 | POLB (0.58) | CYP11B1CYP19A1F9F10GPR132 | |
| SCHEMBL7900710 | 0.75 | MAOB (0.71) | MAOBGPR132MAPK1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124343-A | Substituted phenyl compounds with a substituent having a thienyl ring | RHONE-POULENC RORER LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0805802-B1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LTD (GB) | 2000-08-16 | — | — | EP | disclosed |
| US-6048893-A | Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring | RHONE-POULENC RORER LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |
| EP-0805802-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE-POULENC RORER LIMITED (GB) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022978-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LIMITED (GB) | 1996-08-01 | — | — | WO | disclosed |