Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119481 | 0.85 | MAOB (0.54) | MAOBCYP11B1CYP19A1ALKMAPK1 | |
| SCHEMBL8135327 | 0.83 | MAOB (0.54) | MAOBCYP11B1CYP11B2MAOA | |
| SCHEMBL427002 | 0.83 | MAOB (0.74) | MAOBCYP11B1CYP11B2MAOA | |
| SCHEMBL4424283 | 0.80 | MAOB (0.56) | MAOBMAOA | |
| SCHEMBL12260761 | 0.80 | MAPK1 (0.47) | MAOBCYP11B1CYP19A1CYP11B2MAPK1 | |
| SCHEMBL7673699 | 0.78 | NR1D1 (0.48) | CYP11B1CYP19A1CYP11B2MAPK1 | |
| SCHEMBL4435816 | 0.77 | MAOB (0.57) | MAOBMAOA | |
| SCHEMBL8133729 | 0.77 | CYP19A1 (0.47) | MAOBCYP19A1 | |
| SCHEMBL29468740 | 0.77 | HSD17B10 (0.49) | CYP11B1CYP19A1CYP11B2MAPK1MAOA | |
| SCHEMBL23931747 | 0.76 | GRM5 (0.51) | MAOBCYP11B1CYP11B2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |