Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8123104 | 1.00 | CYSLTR2 (0.50) | CYSLTR2CYSLTR1MEN1NPC1KMT2A | |
| SCHEMBL9255780 | 0.78 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1MEN1NPC1KMT2A | |
| SCHEMBL9255773 | 0.78 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1MEN1NPC1KMT2A | |
| SCHEMBL626121 | 0.75 | CYSLTR1 (0.59) | CYSLTR2CYSLTR1MEN1KMT2A | |
| SCHEMBL30530485 | 0.75 | CYSLTR1 (0.59) | CYSLTR2CYSLTR1MEN1KMT2A | |
| SCHEMBL3331416 | 0.75 | CYSLTR1 (0.59) | CYSLTR2CYSLTR1MEN1KMT2A | |
| SCHEMBL8123334 | 0.75 | CYSLTR2 (0.55) | CYSLTR2CYSLTR1 | |
| SCHEMBL8554761 | 0.75 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1 | |
| SCHEMBL4543898 | 0.75 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1 | |
| SCHEMBL8554758 | 0.75 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604114-B1 | Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists | MERCK FROSST CANADA INC (CA) | 2000-05-03 | — | — | EP | disclosed |
| US-5472964-A | Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1995-12-05 | — | — | US | disclosed |
| WO-1994014815-A1 | DIARYL 5,6-FUSEDHETEROCYCLIC ACIDS AS LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1994-07-07 | — | — | WO | disclosed |
| EP-0604114-A1 | Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1994-06-29 | — | — | EP | disclosed |