Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27002039 | 0.81 | MTNR1A (0.66) | MTNR1AMTNR1BMEN1KMT2ARAB9A | |
| SCHEMBL8130954 | 0.79 | MTNR1A (0.52) | MTNR1AMTNR1BMEN1KMT2ANQO2 | |
| SCHEMBL4053395 | 0.79 | POLB (0.51) | MTNR1AMEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5221315 | 0.78 | HTR2A (0.52) | MTNR1AMTNR1BMEN1KMT2AHTR2C | |
| SCHEMBL5855306 | 0.77 | ALDH1A1 (0.44) | ALDH1A1RAB9A | |
| SCHEMBL12328247 | 0.76 | HSD17B10 (0.63) | MEN1KMT2AKDM4EALDH1A1BLM | |
| SCHEMBL3579011 | 0.76 | ALDH1A1 (0.52) | MTNR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20957057 | 0.76 | HSD17B10 (0.46) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4852727 | 0.75 | ALDH1A1 (0.55) | MEN1KMT2AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL16428954 | 0.75 | SMN1; SMN2 (0.44) | MTNR1AMTNR1BKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526434-B1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA (IT) | 2000-04-19 | — | — | EP | disclosed |
| US-5576318-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-11-19 | — | — | US | disclosed |
| WO-1993003016-A1 | BENZIMIDAZOLONE DERIVATIVES AS 5-HT1A AND 5-HT2 ANTAGONISTS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526434-A1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1993-02-03 | — | — | EP | disclosed |