Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125096 | 0.87 | MEN1 (0.40) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8131719 | 0.83 | SMN1; SMN2 (0.40) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8118204 | 0.80 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL4242110 | 0.79 | NPSR1 (0.39) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL22032209 | 0.79 | LMNA (0.36) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8939971 | 0.79 | FFAR4 (0.41) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22032240 | 0.74 | CA12 (0.41) | KDM4ESMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL21954934 | 0.74 | EZH2 (0.39) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL10320605 | 0.74 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL8068920 | 0.73 | FFAR4 (0.43) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445862-B1 | N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2000-04-19 | — | — | EP | disclosed |
| CN-1038936-C | N-(4-Piperidinyl) (dihydrobenzofuran or dihydro-2H-benzopyran) Carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1998-07-01 | — | — | CN | disclosed |
| US-5262418-A | Laxatives, gastrointestinal disorders | TANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-16 | — | — | US | disclosed |
| US-5185335-A | Administer to mammals to stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-02-09 | — | — | US | disclosed |
| CN-1054598-A | The preparation method of carboxamides derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1991-09-18 | — | — | CN | disclosed |
| EP-0445862-A2 | N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-09-11 | — | — | EP | disclosed |