Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 1.00 |
| ▸ | CCND1 | P24385 | 15/20 | 1.00 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.74 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.74 |
| ▸ | CDK2 | P24941 | 7/20 | 0.74 |
| ▸ | CAMK2B | Q13554 | 7/20 | 0.74 |
| ▸ | CAMK2G | Q13555 | 7/20 | 0.74 |
| ▸ | CAMK2D | Q13557 | 7/20 | 0.74 |
| ▸ | CAMK2A | Q9UQM7 | 7/20 | 0.74 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.74 |
| ▸ | CDK1 | P06493 | 4/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.74 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.74 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.74 |
| ▸ | PRKACA | P17612 | 2/20 | 0.74 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.74 |
| ▸ | PRKACG | P22612 | 2/20 | 0.74 |
| ▸ | PRKACB | P22694 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22566992 | 0.91 | CDK4 (0.83) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL30530825 | 0.86 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL8124103 | 0.86 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL29406635 | 0.86 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL9259173 | 0.85 | CDK4 (0.74) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL13431713 | 0.84 | CDK4 (0.80) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Granulatimide SCHEMBL4238896 | 0.78 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL22566991 | 0.77 | CDK4 (0.65) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14346099 | 0.77 | PARP1 (0.66) | CDK4CCND1CHEK1PARP1 | |
| SCHEMBL14708731 | 0.77 | CDK4 (0.80) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326229-A1 | ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF | TAKEDA PHAMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| US-20090326229-A1 | ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF | TAKEDA PHAMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| WO-2008016184-A1 | ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | disclosed |
| WO-1995007910-A1 | ANTIVIRAL INDOLE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326229-A1 | ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF | XDH, F7, CYP4X1 | CDK4 893/4885CCND1 932/4885CCNE2 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.