Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550029 | 0.92 | CYP19A1 (0.47) | CYP19A1CYP11B2KCNA5CYP11B1CYP17A1 | |
| SCHEMBL8117772 | 0.92 | KCNA5 (0.45) | CYP19A1CYP11B2KCNA5KCNH2CYP11B1 | |
| SCHEMBL8119038 | 0.85 | CYP11B1 (0.43) | CYP19A1CYP11B2CYP11B1ADRB1ADRB3 | |
| SCHEMBL8552624 | 0.84 | CYP19A1 (0.47) | CYP19A1CYP11B2KCNA5CYP11B1CYP17A1 | |
| SCHEMBL8109544 | 0.84 | SMN1; SMN2 (0.44) | CYP19A1KCNA5KCNH2CYP17A1ADRB1 | |
| SCHEMBL8550686 | 0.84 | KCNA5 (0.43) | CYP19A1CYP11B2KCNA5CYP11B1CYP17A1 | |
| SCHEMBL8133883 | 0.82 | CYP17A1 (0.40) | CYP19A1KCNA5CYP17A1ADRB1ADRB3 | |
| SCHEMBL8552459 | 0.81 | CYP17A1 (0.44) | CYP19A1CYP11B2CYP11B1CYP17A1ADRB1 | |
| SCHEMBL8118689 | 0.80 | KCNA5 (0.48) | CYP19A1CYP11B2KCNA5CYP11B1CYP17A1 | |
| SCHEMBL8118468 | 0.80 | KCNA5 (0.45) | CYP19A1CYP11B2KCNA5CYP11B1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037889-A1 | NOVEL COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029686-A1 | NOVEL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |