Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134591 | 0.93 | ALDH1A1 (0.37) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL8124757 | 0.91 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL8128871 | 0.86 | CACNA1B (0.38) | CYP11B2CACNA1BPTGS2 | |
| SCHEMBL8580696 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL10365811 | 0.82 | MAPT (0.41) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL8136984 | 0.82 | KDM4E (0.38) | ALDH1A1MAPTKMT2AKDM4ENPC1 | |
| SCHEMBL10367467 | 0.82 | MAPT (0.44) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL10365659 | 0.81 | GRM5 (0.38) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL8124654 | 0.81 | APP (0.36) | ALDH1A1MAPTLMNAHTTTDP1 | |
| SCHEMBL10367909 | 0.80 | GRM5 (0.36) | ALDH1A1MAPTLMNAMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | claimed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | claimed |
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5935956-A | Pyridazine compounds | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-08-10 | — | — | US | disclosed |
| WO-1998009969-A1 | NOVEL ARYL-PYRIDAZINES | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-03-12 | — | — | WO | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |