Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121601 | 0.81 | RHEB (0.41) | RHEBALDH1A1P2RX7HTR1ASLC6A2 | |
| SCHEMBL8115402 | 0.78 | ALDH1A1 (0.41) | RHEBALDH1A1P2RX7HTR1ASLC6A2 | |
| SCHEMBL30772335 | 0.78 | CA12 (0.50) | RHEBALDH1A1P2RX7L3MBTL1MEN1 | |
| SCHEMBL78713 | 0.78 | CA12 (0.50) | RHEBALDH1A1P2RX7L3MBTL1MEN1 | |
| SCHEMBL8130154 | 0.76 | CASR (0.38) | RHEBALDH1A1P2RX7HTR1ASLC6A2 | |
| Fluoride SCHEMBL28106604 | 0.76 | CA12 (0.48) | RHEBALDH1A1P2RX7L3MBTL1MEN1 | |
| SCHEMBL6325195 | 0.73 | RHEB (0.60) | RHEBALDH1A1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL28046486 | 0.73 | HSP90AA1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2ANPSR1 | |
| SCHEMBL8125043 | 0.72 | ALDH1A1 (0.39) | RHEBALDH1A1P2RX7HTR1ASLC6A2 | |
| SCHEMBL2282004 | 0.72 | GAA (0.35) | ALDH1A1NPSR1HSP90AA1MAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |