Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121294 | 0.81 | LMNA (0.45) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL8125649 | 0.80 | SMN1; SMN2 (0.44) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL919956 | 0.78 | LMNA (0.47) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL8115367 | 0.77 | LMNA (0.44) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL28829811 | 0.77 | MEN1 (0.32) | — | |
| SCHEMBL8131418 | 0.76 | KMT2A (0.40) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL622920 | 0.75 | DDB1 (0.34) | ALDH1A1L3MBTL1 | |
| SCHEMBL8126361 | 0.75 | LMNA (0.47) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL8124447 | 0.75 | LMNA (0.47) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL8124882 | 0.75 | LMNA (0.47) | LMNATDP1SMN1; SMN2ALDH1A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |