Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544271 | 0.81 | LTA4H (0.38) | TDP1ALDH1A1RAB9AL3MBTL1LTA4H | |
| SCHEMBL8129943 | 0.80 | LMNA (0.47) | LMNATDP1SMN1; SMN2CYP19A1GAA | |
| SCHEMBL8124504 | 0.77 | LMNA (0.41) | LMNATDP1SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL8129484 | 0.77 | LMNA (0.47) | LMNATDP1SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL8121673 | 0.77 | LMNA (0.47) | LMNATDP1SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL8125119 | 0.77 | SLC22A12 (0.37) | LMNATDP1ALDH1A1NPY5RFFAR4 | |
| SCHEMBL8116618 | 0.77 | NPY5R (0.37) | LMNATDP1SMN1; SMN2ALDH1A1CYP11B1 | |
| SCHEMBL8125649 | 0.77 | SMN1; SMN2 (0.44) | LMNATDP1SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL8129500 | 0.74 | MAPK8 (0.36) | LTA4H | |
| SCHEMBL8125843 | 0.74 | KMT2A (0.40) | LMNASMN1; SMN2GAAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |