SCHEMBL8124641

SCHEMBL8124641

O=C1[N]c2c(cc(Cl)c(C(F)(F)F)c2[N+](=O)[O-])NC1=O

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.32
ALDH1A1 P00352 3/20 0.32
GLP1R P43220 1/20 0.31
HPGD P15428 2/20 0.31
CYP3A4 P08684 1/20 0.31
ALOX15 P16050 1/20 0.31
HIF1A Q16665 1/20 0.31
TXNRD1 Q16881 1/20 0.31
TXNRD3 Q86VQ6 1/20 0.31
TXNRD2 Q9NNW7 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CCNE2 O96020 1/20 0.30
CCNE1 P24864 1/20 0.30
CDK2 P24941 1/20 0.30
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2A Q12879 1/20 0.30
GRIN2B Q13224 1/20 0.30
GRIN2C Q14957 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3670098 0.86 ABCC8 (0.33) TSHRALDH1A1HPGDCYP3A4ALOX15
SCHEMBL8114972 0.86 ABCC8 (0.33)
SCHEMBL8123914 0.86 ABCC8 (0.33) TSHRCYP3A4LMNATP53RAB9A
SCHEMBL8127539 0.85
SCHEMBL8114652 0.83 TSHR (0.34) TSHRALDH1A1HPGDGRIN2DGRIN3B
SCHEMBL5274587 0.82 TSHR (0.47) TSHRALDH1A1GRIN2DGRIN3BGRIN1
SCHEMBL8555872 0.82 EPAS1 (0.36) TSHRALDH1A1HPGDCYP3A4ALOX15
SCHEMBL8557837 0.81 ABCC8 (0.33)
SCHEMBL8128461 0.81 ABCC8 (0.33) TSHRCYP3A4LMNATP53RAB9A
SCHEMBL3675510 0.80 ABCC8 (0.34) TSHRALDH1A1CYP3A4LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0732942-A4 ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS COCENSYS INC (US) 2000-03-22 EP disclosed
EP-0732942-A1 ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS ACEA PHARMACEUTICALS, INC. (US) 1996-09-25 EP disclosed
WO-1995012417-A1 ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS ACEA PHARMACEUTICALS, INC. (US) 1995-05-11 WO disclosed