Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127806 | 0.88 | GAA (0.49) | HPGDSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL8119099 | 0.82 | MEN1 (0.54) | HPGDSMN1; SMN2HTTLMNAGAA | |
| SCHEMBL1728537 | 0.79 | MAPK14 (0.68) | HPGDMAPK14FFAR1SMN1; SMN2HTT | |
| SCHEMBL8126971 | 0.79 | RNF4 (0.56) | HPGDSMN1; SMN2RECQLALDH1A1LTA4H | |
| SCHEMBL27593863 | 0.76 | HPGD (0.61) | HPGDMAPK14FFAR1SMN1; SMN2HTT | |
| SCHEMBL2851912 | 0.76 | MAPK14 (0.64) | HPGDMAPK14FFAR1SMN1; SMN2HTT | |
| SCHEMBL1680843 | 0.75 | NPC1 (0.71) | HPGDMAPK14FFAR1SMN1; SMN2HTT | |
| SCHEMBL5709300 | 0.75 | HPGD (0.84) | HPGDMAPK14SMN1; SMN2HTTLMNA | |
| SCHEMBL13192876 | 0.74 | HPGD (0.62) | HPGDMAPK14FFAR1SMN1; SMN2HTT | |
| SCHEMBL10133183 | 0.74 | NPC1 (0.75) | HPGDMAPK14LMNARECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988292-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056771-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-17 | — | — | WO | disclosed |