Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127806 | 0.87 | GAA (0.49) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL10057406 | 0.82 | CYP2C9 (0.57) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL8125203 | 0.82 | HPGD (0.54) | MEN1KMT2AGAAALDH1A1HPGD | |
| SCHEMBL10055708 | 0.78 | CYP2C9 (0.55) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL8119567 | 0.78 | ALDH1A1 (0.55) | KMT2AALDH1A1HTTL3MBTL1LMNA | |
| SCHEMBL29221809 | 0.75 | KDM4E (0.56) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL10055513 | 0.75 | CYP2C9 (0.51) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL167573 | 0.74 | MEN1 (0.73) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL1558063 | 0.73 | MEN1 (0.60) | MEN1KMT2ACYP2C9CYP2C19GAA | |
| SCHEMBL17590514 | 0.72 | MEN1 (0.43) | MEN1KMT2ACYP2C9CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988292-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056771-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-17 | — | — | WO | disclosed |