Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NMBR | P28336 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345609 | 0.87 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 | |
| SCHEMBL1041048 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL2035093 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2CYP2C9 | |
| SCHEMBL7159342 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 | |
| SCHEMBL14993551 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 | |
| SCHEMBL4382643 | 0.84 | SIRT2 (0.54) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL8794940 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 | |
| SCHEMBL7988316 | 0.83 | SIRT2 (0.48) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 | |
| Hydrochloric Acid SCHEMBL7987252 | 0.83 | SIRT2 (0.53) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL2490264 | 0.83 | SIRT2 (0.48) | SIRT2CYP11B1CYP11B2ENPP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016514-A2 | 1, 3 AND 1, 3, 5 SUBSTITUTED IMIDAZOLES AS ANTIHYPERTENSIVA | ELDRUG S.A. (GR) | 2009-02-05 | — | — | WO | disclosed |