Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | NMBR | P28336 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125239 | 0.87 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL759 | 0.83 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL2038903 | 0.83 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL6355465 | 0.83 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL1342 | 0.83 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL1924923 | 0.83 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL7269738 | 0.83 | SIRT2 (0.50) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL8687551 | 0.81 | SIRT2 (0.44) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| Hydrochloric Acid SCHEMBL6926362 | 0.81 | SIRT2 (0.44) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL6771514 | 0.81 | SIRT2 (0.44) | SIRT2CYP11B1CYP11B2ENPP2NMBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2000474-A1 | METHOD FOR PRODUCTION OF PEPTIDE THIOESTER COMPOUND | Otsuka Chemical Co., Ltd. (JP) | 2008-12-10 | — | — | EP | disclosed |
| US-20080221152-A1 | 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | ALLERGAN, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| US-6951944-B2 | Production of imidazole derivatives and novel intermediates of the derivatives | AZWELL INC. (JP) | 2005-10-04 | — | — | US | disclosed |
| US-20050043277-A1 | Production of imidazole derivatives and novel intermediates of the derivatives | AZWELL INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1477487-A1 | IMPROVEMENT IN THE PRODUCTION OF IMIDAZOLE DERIVATIVES AND NOVEL INTERMEDIATES OF THE DERIVATIVES | Azwell Inc. (JP) | 2004-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221152-A1 | 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | ADRB2, ADRA2C, ADRA2A | SIRT2 1298/4885CYP11B1 181/4885CYP11B2 84/4885 |
| US-20050043277-A1 | Production of imidazole derivatives and novel intermediates of the derivatives | HRH3, HRH4, HRH2 | SIRT2 1941/4885CYP11B1 3388/4885CYP11B2 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.