Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126352 | 1.00 | GRM6 (0.47) | GRM6SMN1; SMN2LMNATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL7450698 | 0.99 | GRM6 (0.46) | GRM6SMN1; SMN2LMNATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL7450701 | 0.99 | GRM6 (0.46) | GRM6SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL7340659 | 0.85 | MEN1 (0.48) | SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7437948 | 0.84 | MEN1 (0.47) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL8044487 | 0.77 | GRM6 (0.50) | GRM6ALDH1A1CYP19A1ACES1PR1 | |
| SCHEMBL27245241 | 0.77 | GRM6 (0.50) | GRM6ALDH1A1CYP19A1ACES1PR1 | |
| SCHEMBL27245240 | 0.77 | GRM6 (0.50) | GRM6ALDH1A1CYP19A1ACES1PR1 | |
| SCHEMBL9820105 | 0.75 | GRM6 (0.51) | GRM6ALDH1A1CYP19A1ACEMAPT | |
| SCHEMBL23464974 | 0.74 | GRM6 (0.56) | GRM6ACEMAPTS1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822934-B1 | ANTITHROMBOTIC AMIDINOTETRAHYDROPYRIDYLALANINE DERIVATIVES | PFIZER RES & DEV (IE) | 2000-02-09 | — | — | EP | disclosed |
| US-5798352-A | Antithrombotic amidinotetrahydropyridylalanine derivatives | PFIZER INC. (US) | 1998-08-25 | — | — | US | disclosed |