Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.77 |
| ▸ | HTR1D | P28221 | 4/20 | 0.77 |
| ▸ | HTR1B | P28222 | 4/20 | 0.77 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119474 | 0.88 | HTR1A (0.82) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8127323 | 0.87 | HTR1A (0.81) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8121210 | 0.87 | HTR1A (1.00) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8128007 | 0.86 | HTR1A (0.79) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8125601 | 0.85 | HTR1D (0.78) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL8125307 | 0.85 | HTR1A (0.77) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL8136006 | 0.83 | HTR1A (0.74) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8122308 | 0.82 | HTR1A (0.73) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8137992 | 0.82 | HTR1A (0.72) | HTR1AHTR1DHTR1BSLC2A1HTR2C | |
| SCHEMBL8143058 | 0.82 | HTR1D (0.90) | HTR1AHTR1DHTR1BSLC2A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1260781-A | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | CN | claimed |
| CN-1260781-A | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | CN | disclosed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |