Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | S100A4 | P26447 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842406 | 0.75 | PDK2 (0.59) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL31076274 | 0.75 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL31397805 | 0.75 | PDK2 (0.59) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL17942114 | 0.75 | CA1 (0.43) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL31212182 | 0.75 | CA1 (0.43) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL11593604 | 0.74 | S100A4 (0.70) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL29078052 | 0.74 | PDK2 (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15193198 | 0.72 | MAPT (0.47) | MAPTALDH1A1KDM4EHPGDCACNA1B | |
| SCHEMBL8143110 | 0.71 | CES1 (0.55) | — | |
| SCHEMBL3865758 | 0.69 | MMP2 (0.56) | MAPTALDH1A1KDM4EHPGDCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2756041-B1 | ORGANIC ELECTROCHROMIC MATERIALS HAVING HIGH TRANSPARENCY AND HIGH CONTRAST IN THE VISIBLE RANGE | CONSORZIO INTERUNIVERSITARIO NAZ PER LA SCIENZA E TECNOLOGIA DEI MATERIALI INSTM (IT) | 2015-03-04 | — | — | EP | disclosed |
| EP-0760819-B1 | TRICYCLIC DICARBONYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2000-07-19 | — | — | EP | disclosed |
| US-5688803-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0760819-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032205-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-30 | — | — | WO | disclosed |